منابع مشابه
Age dependency of trauma-induced neocortical epileptogenesis
Trauma and brain infection are the primary sources of acquired epilepsy, which can occur at any age and may account for a high incidence of epilepsy in developing countries. We have explored the hypothesis that penetrating cortical wounds cause deafferentation of the neocortex, which triggers homeostatic plasticity and lead to epileptogenesis (Houweling etal., 2005). In partial deafferentation ...
متن کاملEpileptogenesis following neocortical trauma from two sources of disinhibition.
Epileptogenesis following neocortical trauma from two sources of disinhibition. J. Neurophysiol. 78: 2804-2810, 1997. Intracellular and field potential recordings were obtained from superficial and deep neurons from both intact coronal rat somatosensory slices, and from slices which had been acutely divided into a superficial strip of cortex ( approximately 450 micron from the pia) and a deep s...
متن کاملPreparing undercut model of posttraumatic epileptogenesis in rodents.
Partially isolated cortex ("undercut") is an animal model of posttraumatic epileptogenesis. The surgical procedure involves cutting through the sensorimotor cortex and the underneath white matter (undercut) so that a specific region of the cerebral cortex is largely isolated from the neighboring cortex and subcortical regions(1-3). After a latency of two or more weeks following the surgery, epi...
متن کاملChronic Posttraumatic Epilepsy following Neocortical Undercut Lesion in Mice
Posttraumatic epilepsy (PTE) usually develops in a small percentage of patients of traumatic brain injury after a varying latent period. Modeling this chronic neurological condition in rodents is time consuming and inefficient, which constitutes a significant obstacle in studying its mechanism and discovering novel therapeutics for its prevention and treatment. Partially isolated neocortex, or ...
متن کاملRAPID COMMUNICATION Epileptogenesis Following Neocortical Trauma From Two Sources of Disinhibition
Yang, Lie and Larry S. Benardo. Epileptogenesis following neonot directly injured by the mechanical insult. What is the cortical trauma from two sources of disinhibition. J. Neurophysiol. status of GABAergic inhibition in the wake of the storm 78: 2804–2810, 1997. Intracellular and field potential recordings of excitation that follows trauma? Is fast inhibition simply were obtained from superfi...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2010
ISSN: 0013-9580
DOI: 10.1111/j.1528-1167.2010.02816.x